J Hepatol. J Immunol. 2011 Mar 11; 286(10):8609-8619. PLoS One. J Gastroenterol Hepatol. 1998 Jan 01; 160(1):410-8. 2010 Oct; 16(10):1152-6. Am J Physiol Gastrointest Liver Physiol. 2003 May; 37(5):1043-55. 2003 Jan 10; 278(2):927-33. 2020; 144(8):400-412. Caussy C, Hsu C, Singh S, Bassirian S, Kolar J, Faulkner C, Sinha N, Bettencourt R, Gara N, Valasek MA, Schnabl B. Transplantation. Curr Pathobiol Rep. 2013 Sep; 1(3):209-214. Nat Med. Placebo-controlled trial of high-dose atorvastatin in patients with severe cerebral small vessel disease. Liver Int. Gastroenterology. Fibrocyte-like cells recruited to the spleen support innate and adaptive immune responses to acute injury or infection. 2007 Dec; 133(6):2019-28. Bradham CA, Stachlewitz RF, Gao W, Qian T, Jayadev S, Jenkins G, Hannun Y, Lemasters JJ, Thurman RG. 2004 Aug 15; 78(3):324-32. 2004 Dec; 127(6):1659. Hatano E, Bradham CA, Stark A, Iimuro Y, Lemasters JJ. Anti-fibrogenic strategies and the regression of fibrosis. 2006 Jul 27; 82(2):241-50. Nat Immunol. Investigating the role of the extracellular environment in modulating hepatic stellate cell biology with arrayed combinatorial microenvironments. UCSD Profiles is managed by the UC San Diego The renin-angiotensin-aldosterone system in cerebral small vessel disease. High molecular weight adiponectin inhibits proliferation of hepatic stellate cells via activation of adenosine monophosphate-activated protein kinase. 2009 Nov; 58(11):1517-27. 2006 May; 130(6):1562. Nishio T, Iimuro Y, Nitta T, Harada N, Yoshida M, Hirose T, Yamamoto N, Morimoto T. c-Jun-N-terminal kinase drives cyclin D1 expression and proliferation during liver regeneration. Alcohol Clin Exp Res. After being discharged, he attended Temple University, where he majored in mass communication and graduated with honors. Brenner was a writer, director or producer of 115 television documentaries and headed the documentary units of Westinghouse Broadcasting and Metromedia, winning nearly 30 awards including an Emmy, before moving to comedy. The role of gut-derived bacterial toxins and free radicals in alcohol-induced liver injury. J Gastroenterol Hepatol. Lehmann TG, Wheeler MD, Schwabe RF, Connor HD, Schoonhoven R, Bunzendahl H. Tumor necrosis factor alpha prevents tumor necrosis factor receptor-mediated mouse hepatocyte apoptosis, but not fas-mediated apoptosis: role of nuclear factor-kappaB. Obesity and alcohol synergize to increase the risk of incident hepatocellular carcinoma in men. J Gastroenterol Hepatol. 2015; 10(7):e0129743. Am J Physiol. Am J Physiol Heart Circ Physiol. Hepatology. 2003 Oct; 23(5):386-96. J Hepatol. Study of loneliness and wisdom in 482 middle-aged and oldest-old adults: a comparison between people in Cilento, Italy and San Diego, USA. A method for in vitro DNase I footprinting analysis on supercoiled templates. Caussy C, Tripathi A, Humphrey G, Bassirian S, Singh S, Faulkner C, Bettencourt R. Heterozygous Tbk1 loss has opposing effects in early and late stages of ALS in mice. 2020 Feb; 21(2):89-98. 2022 10; 610(7931):366-372. Estriol sensitizes rat Kupffer cells via gut-derived endotoxin. Link between gut-microbiome derived metabolite and shared gene-effects with hepatic steatosis and fibrosis in NAFLD. Autocrine expression of activated transforming growth factor-beta(1) induces apoptosis in normal rat liver. Aging increases the susceptibility of hepatic inflammation, liver fibrosis and aging in response to high-fat diet in mice. Analysis of the collagen alpha 1(I) promoter. 2015 Nov-Dec; 49 Suppl 1:S25-7. Aliment Pharmacol Ther. Gastroenterology. # # # Media Contact: Alma Fisher, 619-543-6163, alfisher@ucsd.edu Miura K, Kodama Y, Inokuchi S, Schnabl B, Aoyama T, Ohnishi H. Hepatocytes do not undergo epithelial-mesenchymal transition in liver fibrosis in mice. Heterogeneity of HSCs in a Mouse Model of NASH. Baeza-Raja B, Goodyear A, Liu X, Lam K, Yamamoto L, Li Y, Dodson GS, Takeuchi T. Cognitive Health of Nonagenarians in Southern Italy: A Descriptive Analysis from a Cross-Sectional, Home-Based Pilot Study of Exceptional Longevity (Cilento Initiative on Aging Outcomes Or CIAO). Bradham CA, Qian T, Streetz K, Trautwein C. NF-kappaB inactivation converts a hepatocyte cell line TNF-alpha response from proliferation to apoptosis. Proc Natl Acad Sci U S A. Biology (Basel). 2021; 12(3):891-920. 2002 Jul; 283(1):C347-57. 1997 Nov; 113(5):1589-98. 2007 Jun; 22 Suppl 1:S73-8. Am J Physiol Gastrointest Liver Physiol. Enhanced sensitivity to DSS colitis caused by a hypomorphic Mbtps1 mutation disrupting the ATF6-driven unfolded protein response. Vollmann EH, Cao L, Amatucci A, Reynolds T, Hamann S, Dalkilic-Liddle I, Cameron TO, Hossbach M, Kauffman KJ, Mir FF, Anderson DG, Novobrantseva T, Koteliansky V. Mesothelin/mucin 16 signaling in activated portal fibroblasts regulates cholestatic liver fibrosis. J Clin Gastroenterol. Science. Scholten D, Reichart D, Paik YH, Lindert J, Bhattacharya J, Glass CK. Yale J Biol Med. 2010 Mar; 51(3):1027-36. Gastroenterology. 2021 09; 191(9):1564-1579. Alzheimer's disease: the vascular connection. 1999 Aug; 21(2):238-45. 2005 Apr; 115(4):849-59. 2012 Jun; 56(6):1283-92. Oh TG, Kim SM, Caussy C, Fu T, Guo J, Bassirian S, Singh S, Madamba EV, Bettencourt R, Richards L, Yu RT, Atkins AR, Huan T. Molecular and cellular mechanisms of liver fibrosis and its regression. Methods Enzymol. 2011 Apr; 25(2):305-17. 15th International Symposium on Cells of the Hepatic Sinusoid, 2010. DNA Cell Biol. J Gastroenterol Hepatol. J Hepatol. Liver Transpl. Expression of collagen genes in the liver. 2002 Sep; 132(3):441-9. 1992 Sep 04; 70(5):777-89. 2001; 160:459-79. Evidence for a common progenitor of epithelial and mesenchymal components of the liver. Biofactors. Hepatology. 1996 Sep; 50(3):656-61. GIV/Girdin is a central hub for profibrogenic signalling networks during liver fibrosis. Hepatology. Nishiura T, Nishimura T, deSerres S, Godfrey V, Bradham CA, Nakagawa T. Role of Kupffer cells and gut-derived endotoxins in alcoholic liver injury. J Immunol. 1990; 14(6):639-45. J Biol Chem. 2012 Nov; 13(11):1072-82. Adv Second Messenger Phosphoprotein Res. 2001 Nov; 34(5):953-63. Transforming growth factor-alpha stimulates proto-oncogene c-jun expression and a mitogenic program in primary cultures of adult rat hepatocytes. Gene expression and cytokine and enzyme activation in the liver after a burn injury. In this role, he leads the School of 2014 Jul 21; 5:4451. Lavalle PC, Labreuche J, Gongora-Rivera F, Jaramillo A. Magness ST, Jijon H, Van Houten Fisher N, Sharpless NE. Immunosuppression, hepatitis B virus variants: Synergistic role in hepatic fibrogenesis. J Clin Exp Hepatol. NF-kappaB activation in Kupffer cells after partial hepatectomy. Inactivation of plasmid reporter gene expression by one benzo(a)pyrene diol-epoxide DNA adduct in adult rat hepatocytes. Sam F, Sawyer DB, Xie Z, Chang DL, Ngoy S. Hepatic stellate cells as a target for the treatment of liver fibrosis. Gao B, Emami A, Zhou R, Lang S, Duan Y, Wang Y, Jiang L. Targeting the Wnt signaling pathway through R-spondin 3 identifies an anti-fibrosis treatment strategy for multiple organs. Gastroenterology. 2004 Feb; 24(4):1758-68. J Clin Invest. Hepatology. Kono H, Nakagami M, Rusyn I, Connor HD, Stefanovic B. Mechanisms of alcoholic liver disease: cytokines. Development of a new, simple rat model of early alcohol-induced liver injury based on sensitization of Kupffer cells. 2012 Mar; 10(3):285-90.e1. Regulatory elements in the 5'-flanking region and the first intron contribute to transcriptional control of the mouse alpha 1 type I collagen gene. Curcumin blocks cytokine-mediated NF-kappa B activation and proinflammatory gene expression by inhibiting inhibitory factor I-kappa B kinase activity. Identification of Novel Fibrosis Modifiers by InVivo siRNA Silencing. Hepatology. Hellerbrand C, Jobin C, Iimuro Y, Licato L, Sartor RB. Differential role of I kappa B kinase 1 and 2 in primary rat hepatocytes. Mol Endocrinol. Cell Metab. Hepatology. J Clin Invest. Dig Dis. Bradham CA, Schemmer P, Stachlewitz RF, Thurman RG. Hemizygous deletion of Tbk1 worsens neuromuscular junction pathology in TDP-43G298S transgenic mice. 2005 Jun 10; 280(23):21763-72. 2005 May; 41(5):1085-95. 2021 07 20; 118(29). Vice Chancellor, UC San Diego Health Sciences. Dr. David Brenner is vice chancellor for health sciences at the University of California, San Diego. In this role, he leads the School of Medicine, Skaggs School of Pharmacy and Pharmaceutical Sciences at University of California, San Diego, and UC San Diego Health. Bloomer J, Bruzzone C, Zhu L, Scarlett Y, Magness S. Mediation by NF-kappa B of cytokine induced expression of intercellular adhesion molecule 1 (ICAM-1) in an intestinal epithelial cell line, a process blocked by proteasome inhibitors. PLoS One. Comparison of human and bovine protoporphyria. The enteropathy of prostaglandin deficiency. Best Pract Res Clin Gastroenterol. What is the potential role of antifibrotic agents for the treatment of liver disease? Mutation of the 5'-untranslated region stem-loop structure inhibits a1(I) collagen expression in vivo. 2005 Jun; 42(6):850-9. 2016 08; 44(3):287-99. Liver regeneration is suppressed in small-for-size liver grafts after transplantation: involvement of c-Jun N-terminal kinase, cyclin D1, and defective energy supply. J Biol Chem. Koyama Y, Wang P, Liang S, Iwaisako K, Liu X, Xu J, Zhang M, Sun M, Cong M, Karin D, Taura K. Liver inflammation and fibrosis. Moderate alcohol drinking: effects on the heart and liver. Inhibition of nuclear factor kappaB and phosphatidylinositol 3-kinase/Akt is essential for massive hepatocyte apoptosis induced by tumor necrosis factor alpha in mice. L-glutamine and L-asparagine stimulate ODC activity and proliferation in a porcine jejunal enterocyte line. Bruno C, Sieverding K, Freischmidt A, Satoh T, Walther P, Mayer B, Ludolph AC, Akira S, Yilmazer-Hanke D, Danzer KM, Lobsiger CS. To return to the graph. Techniques to measure nucleic acid-protein binding and specificity. Moreno M, Gonzalo T, Kok RJ, Sancho-Bru P, van Beuge M, Swart J, Prakash J, Temming K, Fondevila C, Beljaars L, Lacombe M, van der Hoeven P, Arroyo V, Poelstra K. Hepatic progenitors for liver disease: current position. Kweon YO, Goodman ZD, Dienstag JL, Schiff ER, Brown NA, Burchardt E, Schoonhoven R. Akt protects mouse hepatocytes from TNF-alpha- and Fas-mediated apoptosis through NK-kappa B activation. 2000 Jun 01; 95(11):3568-77. Gastroenterology. 2011 Jul; 179(1):189-98. Stroke. Meng F, Wang J, Ge J, Fan X, Wang B, Han L. Innate immunity in alcoholic liver disease. 1998 Sep; 13 Suppl:S93-5. Inhibition of collagen alpha 1(I) expression by the 5' stem-loop as a molecular decoy. Following more than 15 years of exceptional service as vice chancellor for Health Sciences (VCHS), David A. Brenner, MD, will step down on June 30, 2022 to focus Xu Y, Bialik S, Jones BE, Iimuro Y, Kitsis RN, Srinivasan A. Porphyrias. Kim RG, Nguyen P, Bettencourt R, Dulai PS, Haufe W, Hooker J. Sitagliptin vs. placebo for non-alcoholic fatty liver disease: A randomized controlled trial. Interleukin-6 increases rat metalloproteinase-13 gene expression through stimulation of activator protein 1 transcription factor in cultured fibroblasts. Bataller R, Paik YH, Lindquist JN, Lemasters JJ. J Clin Immunol. 2003 May; 73(1):44-52. 2016; 34(5):589-96. 1999 Jul; 5(4):282-93. Gastroenterology. Hepatology. 1989 Sep; 30(9):1220-4. Fra, Fra away: the complex role of activator protein 1 in liver injury. Cellular differentiation causes a selective down-regulation of interleukin (IL)-1beta-mediated NF-kappaB activation and IL-8 gene expression in intestinal epithelial cells. Brenner edited blockbuster hits including 2012, Independence Day and Born On The Fourth Of July, for which he won his Oscar in 1990. 5' stem-loop of collagen alpha 1(I) mRNA inhibits translation in vitro but is required for triple helical collagen synthesis in vivo. Dig Dis Sci. Fibrogenesis and type I collagen gene regulation. 2003 Nov; 285(5):G949-58. Gastroenterology. Am J Physiol Gastrointest Liver Physiol. Enomoto N, Schemmer P, Ikejima K, Takei Y, Sato N. Mice lacking inducible nitric oxide synthase have improved left ventricular contractile function and reduced apoptotic cell death late after myocardial infarction. 2011 Apr; 300(4):G516-25. J Hepatol. AIDS. 2016 07; 111(7):986-94. The Role of NADPH Oxidases (NOXs) in Liver Fibrosis and the Activation of Myofibroblasts. Next-generation academic medicine. 1989 Aug 11; 17(15):6055-64. 1999 Apr 15; 162(8):4447-54. Schnabl B, Hu K, Mhlbauer M, Hellerbrand C, Stefanovic B. 2012 Nov; 122(11):4280-2. 2000 Jul; 279(1):G100-6. J Clin Invest. Protection from liver fibrosis by a peroxisome proliferator-activated receptor d agonist. Age (Dordr). 1999 Jun; 29(6):1680-9. 2009 Jul; 119(7):1858-70. c-Jun N-terminal kinase-1 from hematopoietic cells mediates progression from hepatic steatosis to steatohepatitis and fibrosis in mice. 2022 08; 42(3):233-249. 2019 Feb; 3(2):180-192. Toll-like receptor 2 and palmitic acid cooperatively contribute to the development of nonalcoholic steatohepatitis through inflammasome activation in mice. 1995 Jun; 21(6):303-7. Arch Biochem Biophys. Agreement between TOAST and CCS ischemic stroke classification: the NINDS SiGN study. J Clin Invest. Cardiovascular health of nonagenarians in southern Italy: a cross-sectional, home-based pilot study of longevity. Human hepatic stellate cells express CCR5 and RANTES to induce proliferation and migration. 2013 Sep 16; 202(6):951-66. 2020 05; 158(6):1728-1744.e14. Nonalcoholic fatty liver disease with cirrhosis increases familial risk for advanced fibrosis. Rippe RA, Schrum LW, Stefanovic B, Sols-Herruzo JA. 2005 Feb; 115(2):209-18. Dig Dis. J Clin Invest. 2007 Nov; 13(11):1324-32. J Clin Invest. Cui J, Philo L, Nguyen P, Hofflich H, Hernandez C, Bettencourt R. Novel 3D Magnetic Resonance Elastography for the Noninvasive Diagnosis of Advanced Fibrosis in NAFLD: A Prospective Study. Rhoads JM, Argenzio RA, Chen W, Graves LM, Licato LL, Blikslager AT, Smith J, Gatzy J. J Hepatobiliary Pancreat Sci. 2015 Feb; 4(1):34-47. 2020 12; 72(6):2182-2196. 1989 Aug 15; 49(16):4446-51. J Biol Chem. Hepatology. Multiplex short tandem repeat profiling of immortalized hepatic stellate cell line Col-GFP HSC. 2015 Dec; 149(7):1784-93. Hepatology. Kodama Y, Taura K, Miura K, Schnabl B, Osawa Y. Molecular pathogenesis of liver fibrosis. Differential requirement for c-Jun NH2-terminal kinase in TNFalpha- and Fas-mediated apoptosis in hepatocytes. 2001 Jan; 280(1):G139-48. Hepatology. 1990 Dec; 283(2):447-57. Their daughter, Laura, is a medical student at Columbia and their son, Nathan, attends the 2011 Jul; 41(7):683-6. Nucleic Acids Res. 2003 Jul 15; 76(1):28-37. Gastroenterology. 2001 Nov; 281(5):G1279-89. 2003 Feb; 124(2):445-58. Cell Host Microbe. Medicina (Kaunas). 2011 May; 53(5):1730-41. The Clinical Research Forum and Association of American Physicians disagree with criticism of the NIH Roadmap. Semin Liver Dis. Mol Biol Med. Hellerbrand C, Stefanovic B, Giordano F, Burchardt ER. Of Mice and Men and Nonalcoholic Steatohepatitis. Meurer SK, Alsamman M, Sahin H, Wasmuth HE. 2004 Apr; 18(6):720-2. Blood. 2005 Sep-Oct; 7(9-10):1346-55. 2022 Mar; 1(1):pgac006. Gbele E, Froh M, Arteel GE, Uesugi T, Hellerbrand C, Schlmerich J. Adler DH, Cogan JD, Phillips JA, Schnetz-Boutaud N, Milne GL, Iverson T, Stein JA. Correlation between liver histology and novel magnetic resonance imaging in adult patients with non-alcoholic fatty liver disease - MRI accurately quantifies hepatic steatosis in NAFLD. 2020 05; 72(5):946-959. Sidahmed E, Cornellier ML, Ren J, Askew LM, Li Y, Talaat N, Rapai MS, Ruffin MT, Turgeon DK. 2010 Jul; 139(1):323-34.e7. 2001 Aug 17; 89(4):351-6. 2022 Apr 04. He will assume his new role effective September 14. Sinusoid, 2010 Iimuro Y, Lemasters JJ ; 17 ( 15 ).. 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